New research indicates that individuals who come off new slimming jabs like Wegovy and Mounjaro may regain lost weight much more quickly than those who halt traditional lifestyle plans.
Findings released in a leading medical journal demonstrates that while obese individuals frequently drop a large proportion of their body weight while using the jabs, the mass comes back at an average rate of 0.8 kg per month upon discontinuation.
"People purchasing these drugs must be aware of the danger of rapid rebound weight gain when the treatment is stopped," warns lead investigator Dr. Susan Jebb.
This pace of regain means a return to original weight in about one and a half years.
Analyzing Treatments
The study, which looked at dozens of studies involving over 9,000 of participants, compared the effects of the injectable medications with other pills.
Scientists emphasize that individuals who shed pounds through diet and exercise generally have a more gradual weight regain—around 0.1 kg a month—after stopping.
Understanding the Quick Rebound
Nutrition scientists believe the mode of action of the drugs is key to understanding the accelerated regain.
These medications imitate a natural hormone called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Sustained high doses of the hormone levels far above than the body's typical production might result in the body to produce less of its own natural GLP-1, and could diminish sensitivity to its actions," said Dr. Adam Collins, a nutrition specialist.
"Stopping of this medication results in hunger is unsuppressed, making overeating far more likely."
An Ongoing Condition?
Medical guidelines recommend the injections for people with weight-linked health risks, accompanied by recommended lifestyle changes.
Professionals say that, considering the significant potential of relapse, the therapy should be considered ongoing.
This opinion is echoed by pharmaceutical companies, who say that the findings "underscore the chronic character of excess weight," comparing it to managing conditions like hypertension.
Patient Testimonies
People who have come off the jabs report a intense return of appetite.
"I experienced something flipping and you're instantly extremely hungry," recalled an individual.
The struggle is exacerbated if patients have not adopted lasting lifestyle or habit changes during therapy.
Significant Interest
Survey data show that millions of adults in the UK have tried these injections in the last 12 months, with desire continuing to grow.
- Use is more common among females compared to men.
- The middle-aged demographic shows the highest level of interest.
- A large proportion obtain the medications through private prescriptions rather than public health services.
Finally, experts stress that while the jabs are powerful agents for weight loss, they are not a magic solution and long-term success likely depends on ongoing lifestyle changes.
